Notice: Function _load_textdomain_just_in_time was called incorrectly. Translation loading for the wordpress-seo domain was triggered too early. This is usually an indicator for some code in the plugin or theme running too early. Translations should be loaded at the init action or later. Please see Debugging in WordPress for more information. (This message was added in version 6.7.0.) in /var/www/html/wp-includes/functions.php on line 6260 Vitamins (high-dose) - Nutraceuticals World

What are you searching for?

Sign in
Research

Vitamins (high-dose)

Author Image

By: Sean Moloughney

Editor, Nutraceuticals World

Indication: Stroke

Source: Stroke, November 2005;36(11): 2404-9.

Research: A previous report from the Vitamin Intervention for Stroke Prevention trial (VISP) intention-to-treat analysis did not show efficacy of combined vitamin therapy for recurrent vascular events in patients with non-disabling stroke. After these results were published, researchers went back and analyzed a subgroup of 2155 subjects more likely to respond to treatment. For this analysis, researchers excluded patients with low and very high B12 levels at baseline (637 pmol/L, representing the 25th and 95th percentiles), to exclude those likely to have B12 malabsorption or to be taking B12 supplements outside the study and patients with significant renal impairment.

Results: When the research team compared results of low-dose vitamin versus high-dose vitamin therapy and found that high-dose vitamin supplements reduced recurrent stroke, death and heart disease by 21%. Further, when researchers subdivided patients by baseline levels of vitamin B12, thus identifying those with difficulties absorbing the vitamin, the differences between the low-dose and high-dose groups became greater. As such, researchers indicated that the response to vitamin therapy for lowering homocysteine largely depends on the vitamin B12 status of patients.

Add us as a preferred source on Google

Get the latest Nutraceuticals World news, insights and analysis in your Google Search and AI experiences.

Add Nutraceuticals World as a preferred source on Google (opens in a new tab)

Keep Up With Our Content. Subscribe To Nutraceuticals World Newsletters

Topics